Sometimes, the service has occasional (and temporary) issues caused by load, a product issue / bug, or even a deliberate attempt to disrupt the site from external sources.
As we Tweeted earlier, we were aware of a couple of windows of instability today.
The best thing to do in these cases is to try again later. Twitter is a distributed system, so depending on the specific endpoints you are using, results may sometimes differ due to eventual consistency on the backend.
Thanks, and apologies for any inconvenience you may experience.