Hi @madadev_es - You can search for Tweets with Hashtags and negate Retweets (with the operator -is:retweet). In order to only capture the Tweets that are replies, you’d need to parse the search results that you’re returned and look for Tweets that have a non null “in_reply_to…” object (there are several objects in the Tweet payload that you could choose to look at: in_reply_to_status_id, in_reply_to_status_id_str, in_reply_to_user_id, in_reply_to_user_id_str, and in_reply_to_screen_name).
You can read more about Tweets objects here: https://developer.twitter.com/en/docs/tweets/data-dictionary/overview/tweet-object
And you can read more about the Premium Operators here: https://developer.twitter.com/en/docs/tweets/search/overview/premium
Best,
Kevin