Taylor - thanks for reaching out to community.
First practical use case: demo ability to manage brands & breaking news, re: second half of slide deck @ http://infotec.org/wp-content/uploads/2011/04/InfotecInno_Augeri.pdf
Second practical use case: Twitter list on missing people (Amber alerts / Silver Alerts) @ http://twitter.com/#!/aghilmort/missing-people) - experimenting with turning that into a Paper.li
Third practical use case: MightyMoRiver project to track Missouri River flooding - by day we use twitter (@MightyMoRiver), by night we use Crowdmap (http://mightymoriver.crowdmap.com), and we curate a Paper.li from related tweets (http://v.gd/mmr_paper) - all cr: http://v.gd/mmr_highlights
From personal perspective, use Twitter to stay in touch with folks & to get fresh perspectives (keep a perspectives list) and to tweet out posts on my thoughts about how we can collectively share and integrate info (http://chris-augeri.com/blog).
All in all, find platform & API very useful, along with RSS feeds (API good, but for many apps, RSS suffices) - RSS for lists would be big+, please keep RSS for search.
Also, big fan of Twitter + APIGEE - e.g., that's what powered the second real experiment listed above.
Hope this helps, and keep up the good work.