Absolutely, [node:10389] is the way to go here.
Using the sample, you will receive a random selection of Tweets, about 1% of all Tweets, but in your example, it means you may miss a majority of Tweets related to the NASA mission you are interested in, and you will have to manually filter as a second step to extract them.
However, using the filtering endpoint, not only you will exclusively gather Tweets matching at least one of the keywords you are tracking, you may actually receive a majority of them, if not all of them, as long as they account for less than roughly 1% of the full firehose.