@adamdobrin:
To pull data via our Ads API, there are four pieces of information needed to make a request: the consumer_key and consumer_secret (these belong to the app) as well as the token and secret (these belong to the user). For a majority of Ads API users, one approved app ID will provide the necessary authentication credentials to make calls to our API to pull data for any ad accounts you have access to. For information on granting access to multiple accounts/users, please refer to our Obtaining Ads Account Access documentation as well as this forum post.
Please let me know if you have a specific use case requiring multiple app IDs.
Finally, the following Getting Started documentation describes the differences and relationships between users (@handles) and ads accounts.